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About Black Seed Oil in Burleigh Heads

Thymoquinone (TQ), the main bioactive component of Nigella Sativa, has been found

to exhibit anticancer effects in numerous preclinical studies. Due to its multi targeting

nature, TQ interferes in a wide range of tumorigenic processes and counteracts

carcinogenesis, malignant growth, invasion, migration, and angiogenesis. Moreover, TQ can specifically sensitize tumour cells toward conventional cancer treatments (e.g., radiotherapy, chemotherapy, and immunotherapy) and simultaneously minimize

therapy-associated toxic effects in normal cells. In this review, we summarized the

adjuvant potential of TQ as observed in various in vitro and in vivo animal models and

discussed the pharmacological properties of TQ to rationalize its supplementary role in

potentiating the efficacy of standard therapeutic modalities namely surgery, radiotherapy, chemotherapy, and immunotherapy. Altogether, we suggest further

comprehensive evaluation of TQ in preclinical and clinical levels to delineate its

implied utility as a novel complementary adjuvant therapy for cancer treatment.

Introduction

For the last five decades, large-scale “war on cancer” leads to significant progress in the

development of new therapeutic options and more in-depth insights about various

malignancies. Despite the emergence of numerous treatment strategies such as

chemotherapeutic agents, small molecule inhibitors, specific gene, or protein targeting

so-called smart drugs, and immunotherapies that are found to be effective in the

treatment of some form of cancers (e.g., childhood leukaemia, human epidermal

growth factor receptor 2-positive breast cancer), cancer death rate, in general, has not

changed substantially (only 5% since 1950; Sung et al., 2012). According to Centres for

Disease control and Prevention (CDC), cancer is the second leading cause of death in

US (591, 699 deaths registered in 2015–2016), almost catching up heart diseases

(https://www.

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